Eficacia del albendazol comparado con el mebendazol en nematodiasis en estudiantes de I.S.T. Reyna de las Américas - Iquitos, 2011

Abstract

OBJETIVO Determinar la eficacia del albendazol comparado con mebendazol en nematodiasis en estudiantes del I.S.T. “Reyna de las Américas” – Iquitos, 2011. Materiales y Métodos: Se realizó un estudio prospectivo, longitudinal, comparativo, abierto y aleatorio en la Institución Educativa Superior Tecnológica “Reyna de las Américas” – (Iquitos-Perú), desde febrero a abril del 2011. Se evaluaron 270 estudiantes de ambos sexos pertenecientes a esta Institución Educativa Superior Tecnológica “Reyna de las Américas” con diagnóstico de Ascariasis y Trichuriasis, entre las edades de 18 a 25 años, para determinar si mostraban parasitosis por Ascaris lumbricoides o Trichuris trichiura en el examen general de heces. Los estudiantes fueron distribuidos aleatoriamente en dos grupos, uno tratado con albendazol 400 mg dosis única y otro con Mebendazol 100 mg dividido en dos dosis diarias (200 mg), en ambos casos durante 3 días. Se realizaron evaluaciones parasitológicas los días 1 y 14 posteriores a la última dosis del tratamiento asignado. Todas las muestras de heces se procesaron en el Laboratorio del Instituto Superior Tecnológico “Reyna de las Américas”.

OBJECTIVE: Determine the effectiveness of albendazole compared to mebendazole in nematodiasis in IST students "Queen of the Americas" - Iquitos, 2011. Materials and Methods: We performed a prospective, longitudinal, comparative, open randomized Higher Technological Educational Institution "Queen of the Americas" - (Iquitos, Peru), from February to April 2011. We evaluated 270 students of both sexes belonging to the Higher Technological Educational Institution "Queen of the Americas" with a diagnosis of Ascariasis and trichuriasis. Students between 18 and 25 years were selected if they showed Ascaris lumbricoides and Trichuris trichiura in the general examination of feces. Students were randomized into two groups, one treated with albendazole 400 mg single dose and one with mebendazole 600 mg daily in two divided doses, both for 3 days. Parasitological assessments were performed on days 1 and 14 after the last dose of the assigned treatment. All stool samples were processed at the Laboratory Institute of Technology "Queen of the Americas." Results: 45% (270/600) of students with positive diagnosis for Ascaris lumbricoides and Trichuris trichiura were aged between 18 and 25. The most common symptom was stomach pain (32%) in the albendazole group and metallic taste (34%) in group of mebendazole. In 13% of the group of group of albendazole and mebendazole group 3% of the parasites showed 1er dia postratamiento, was also observed reinfestation day 14 post-treatment 8 (30%) in the albendazole group and 3 (11%) in the mebendazole group. Coproparasitológica efficacy with albendazole was 97% and 52% with the mebendazole. Conclusion: We conclude that albendazole is more effective the drug mebendazole in the diagnosis of Ascaris lumbricoides and Trichuris trichiura in the IST students "Queen of the Americas" - Iquitos, 2011.